Cell Reprogramming Unit

Cell Reprogramming Unit is located within the premises of Inbiomed started in the Spring of 2010. It is based on the generation of pluripotent cell lines (iPSC) from adult somatic cells. This technology enables the generation of cell lines from patients' cells so they can be applied to the development of in vitro models of disease. The main goal of this unit is to make this technology available and optimize the protocols for iPSC generation from patients' cells with well characterized pathologies, such as neurodegenerative diseases or cancer, with special consideration to the research programs bieng carried on at Inbiomed.

Technology Support

As a technology focussed unit, this unit will develop the neccesary technological means for efficient, reproducible and cost effective cellular reprogramming. Initially we use the lentiviral transfer of reprogramming genes (Yamanaka cocktail: Oct4, Sox2, Klf4 and c-Myc) through direct collaboration with the Viral Vectors Unit.

Research

This unit is interested in the mechanisms involved in pluripotency induction and maintainace, in direct collaboration with stem cell biology research programs and cancer stem cell research at Inbiomed.

Staff

Unit Head: Luciano Vellón. (lvellon@inbiomed.org)
Technical support: Sara Pozo Fernández