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El empleo de la apoferritina para dirigir drogas

Escrito el 16/05/2016

Investigadores de Inbiomed colaboran en la publicación de un nuevo trabajo científico

Abstract:

We demonstrate a straightforward method to encapsulate siRNA into naturally available and unmodified
human apoferritin. The encapsulation into apoferritin is independent of the sequence of the siRNA and
provides superior protection for those sensitive molecules. High efficiency in transfection can be achieved
in human tumorigenic cells, human primary mesenchymal stem cells (hMSC) and peripheral blood
mononuclear cells (PBMCs). In contrast to Lipofectamine, highly effective gene silencing can be achieved
with ferritin as the delivery agent in both tumor cells and PBMCs at low siRNA concentrations (10 nM). As
an endogenous delivery agent, apoferritin does not induce immune activation of T- and B-cells in human
PBMCs. Apoferritin shows intrinsic anti-inflammatory effects and apoferritin-mediated delivery shows a
preference for immune-activated T- and B-cells, a natural selectivity which may turn useful for drug
delivery in case of infections or inflammatory diseases.

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